Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 7/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31612321 | 1.00 | CYP1A2 (0.50) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL5573799 | 0.85 | ASIC3 (0.53) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL7702432 | 0.81 | CYP1A2 (0.48) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL30447338 | 0.79 | ASIC3 (0.63) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL10705668 | 0.79 | ASIC3 (0.63) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL14849821 | 0.78 | CYP2A6 (0.58) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL5572006 | 0.78 | ASIC3 (0.52) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL5573818 | 0.78 | ASIC3 (0.52) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL28488853 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 | |
| SCHEMBL12462976 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP1A1CYP1B1CYP2A6ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158146-A1 | HSP70 Inhibitors and Methods of Using Same | THE WISTAR INST (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158146-A1 | HSP70 Inhibitors and Methods of Using Same | THE WISTAR INST (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158146-A1 | HSP70 Inhibitors and Methods of Using Same | THE WISTAR INST (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2021202540-A1 | HSP70 INHIBITORS AND METHODS OF USING SAME | THE WISTAR INSTITUTE (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158146-A1 | HSP70 Inhibitors and Methods of Using Same | HSPA2, HSPBP1, HSP90AB1 | CYP1A2 3538/4885CYP1A1 3329/4885CYP1B1 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.