Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24247821 | 0.88 | EGLN1 (0.36) | ROCK2 | |
| SCHEMBL23889140 | 0.79 | KMT2A (0.35) | P2RY12ROCK2 | |
| SCHEMBL19675109 | 0.79 | L3MBTL1 (0.43) | — | |
| SCHEMBL23889073 | 0.78 | PARP10 (0.38) | ROCK2 | |
| SCHEMBL21947217 | 0.77 | CYP1A2 (0.39) | ROCK2 | |
| SCHEMBL20229842 | 0.76 | ROCK2 (0.38) | ROCK2ACACB | |
| SCHEMBL23889098 | 0.76 | ROCK2 (0.41) | ROCK2 | |
| SCHEMBL19675358 | 0.75 | ROCK2 (0.44) | ROCK2 | |
| SCHEMBL20229850 | 0.74 | HRH3 (0.38) | ROCK2 | |
| SCHEMBL19902548 | 0.74 | PDE4D (0.39) | ROCK2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402790-B1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2021-10-06 | — | — | EP | disclosed |