Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL2389436 | 0.86 | PTGS1 (0.44) | MEN1KMT2AKDM4EALDH1A1RECQL | |
| SCHEMBL2389238 | 0.84 | L3MBTL1 (0.46) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL10223330 | 0.81 | L3MBTL1 (0.65) | KDM4EALDH1A1L3MBTL1CYP2D6 | |
| Oxalic Acid SCHEMBL2390867 | 0.80 | PTGS2 (0.49) | MEN1KMT2AKDM4EALDH1A1CYP2C9 | |
| Oxalic Acid SCHEMBL5523774 | 0.79 | KMT2A (0.51) | MEN1KMT2AKDM4EALDH1A1MAPK1 | |
| SCHEMBL2890863 | 0.77 | PTGS1 (0.54) | KDM4EALDH1A1CYP2C9RECQLFFAR1 | |
| SCHEMBL29393183 | 0.73 | PTGS2 (0.64) | KDM4EALDH1A1CYP2C9RECQLPTGS1 | |
| SCHEMBL66533 | 0.73 | PTGS2 (0.64) | KDM4EALDH1A1CYP2C9RECQLPTGS1 | |
| SCHEMBL1345158 | 0.73 | PTGS2 (0.64) | KDM4EALDH1A1CYP2C9RECQLPTGS1 | |
| SCHEMBL66534 | 0.73 | PTGS2 (0.64) | KDM4EALDH1A1CYP2C9RECQLPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012964-B2 | 9-substituted 8-oxoadenine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-09-06 | — | — | US | disclosed |