Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.49 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL2389436 | 0.83 | PTGS1 (0.44) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL2319534 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL6903957 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| Oxalic Acid SCHEMBL2389235 | 0.80 | MEN1 (0.47) | PTGS1KDM4ERECQLALDH1A1MAPK1 | |
| SCHEMBL2390872 | 0.79 | MEN1 (0.45) | PTGS2PTGS1MAPTKDM4ECYP3A4 | |
| SCHEMBL3674499 | 0.79 | PTGS2 (0.69) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL9425565 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL66533 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL2391075 | 0.78 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2MAPT | |
| SCHEMBL1345158 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012964-B2 | 9-substituted 8-oxoadenine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-09-06 | — | — | US | disclosed |