Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 3/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901080 | 0.79 | ELANE (0.50) | F2MAPK1ELANEPLAUKLKB1 | |
| SCHEMBL31391671 | 0.79 | ELANE (0.50) | F2MAPK1ELANEPLAUKLKB1 | |
| SCHEMBL31636018 | 0.78 | LPL (0.40) | PRMT5WDR77BACE1ROCK1DGAT1 | |
| SCHEMBL19665906 | 0.78 | LIPG (0.37) | PRMT5WDR77BACE1ROCK1LIPG | |
| SCHEMBL26390707 | 0.77 | LPL (0.38) | PRMT5WDR77BACE1ROCK1LIPG | |
| SCHEMBL31391678 | 0.75 | GABRA1 (0.39) | MAPK1ELANE | |
| SCHEMBL30581655 | 0.75 | USP30 (0.46) | PRMT5WDR77USP30 | |
| SCHEMBL26390720 | 0.75 | USP30 (0.46) | PRMT5WDR77USP30 | |
| SCHEMBL24137829 | 0.75 | PRMT5 (0.43) | PRMT5WDR77BACE1BACE2ROCK1 | |
| SCHEMBL26390694 | 0.74 | USP30 (0.43) | PRMT5WDR77USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021197467-A1 | MULTI-TARGET ANTI-TUMOR COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海华汇拓医药科技有限公司 | 2021-10-07 | — | — | WO | disclosed |