Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901403 | 0.82 | ADAMTS5 (0.32) | ADAMTS5MMP2 | |
| SCHEMBL17884921 | 0.81 | ADAMTS5 (0.49) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL22201064 | 0.69 | ADAMTS5 (0.77) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL22201074 | 0.68 | PLA2G10 (0.32) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL29835161 | 0.66 | ADAMTS5 (0.54) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL23727238 | 0.66 | ADAMTS5 (0.54) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL24927817 | 0.65 | ADAM17 (0.41) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL29978673 | 0.65 | ADAM17 (0.41) | ADAMTS5ADAM17MMP2MMP14 | |
| SCHEMBL29835186 | 0.65 | ADAMTS5 (0.56) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL19709386 | 0.65 | ADAMTS5 (0.56) | ADAMTS5ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309614-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309614-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | ADAMTS1, ADAMTS5, ADAMTS7 | ADAMTS5 2/4885ADAM17 8/4885MMP2 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.