SCHEMBL23901647

SCHEMBL23901647

NC1CCN(c2ccc(C(=O)N3CCOC3c3ccccc3)c(Cl)c2)C1

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
NOTUM Q6P988 6/20 0.41
NAMPT P43490 1/20 0.38
KHK P50053 1/20 0.37
AR P10275 1/20 0.35
HSP90AA1 P07900 1/20 0.35
P2RX7 Q99572 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23901530 0.84 AVPR2 (0.43) AVPR2NOTUMNAMPTKHKP2RX7
SCHEMBL23901730 0.80 L3MBTL1 (0.49) L3MBTL1HSP90AA1P2RX7
SCHEMBL23901481 0.79 AVPR2 (0.42) AVPR2NOTUMP2RX7
SCHEMBL23901480 0.79 AVPR2 (0.42) AVPR2NOTUMP2RX7
SCHEMBL23901529 0.79 AVPR2 (0.42) AVPR2P2RX7
SCHEMBL23901667 0.73 ALDH1A1 (0.47) AVPR2
SCHEMBL25453338 0.73 AVPR2 (0.55) AVPR2NOTUMP2RX7
SCHEMBL25453375 0.71 AVPR2 (0.50) AVPR2NOTUMP2RX7
SCHEMBL25453329 0.71 AVPR2 (0.50) AVPR2NOTUMP2RX7
SCHEMBL23901479 0.70 L3MBTL1 (0.51) L3MBTL1HSP90AA1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021202600-A1 SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ THE SCRIPPS RESEARCH INSTITUTE (US) 2021-10-07 WO disclosed