Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048892 | 0.87 | HTT (0.59) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL5357024 | 0.85 | LMNA (0.54) | HTTLMNASMN1; SMN2KMT2APOLB | |
| SCHEMBL8266566 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2KMT2APOLBNPSR1 | |
| SCHEMBL306383 | 0.83 | PDK1 (0.71) | HTTLMNASMN1; SMN2KMT2APOLB | |
| SCHEMBL28208041 | 0.83 | HTT (0.65) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL10264545 | 0.83 | SMN1; SMN2 (0.67) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL6470532 | 0.82 | HTT (0.58) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL6616170 | 0.81 | ALDH1A1 (0.66) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL1142037 | 0.81 | HTT (0.72) | HTTHSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL7631829 | 0.81 | LMNA (0.67) | HTTLMNASMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022213204-A9 | CARBOXAMIDE PYROLOPYRAZINE AND PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF MYT1 AND USE THEREOF IN THE TREATMENT OF CANCER | REPARE THERAPEUTICS INC. (CA) | 2023-11-16 | — | — | WO | disclosed |
| WO-2022213204-A1 | COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS | REPARE THERAPEUTICS INC. (CA) | 2022-10-13 | — | — | WO | disclosed |
| WO-2021195782-A1 | METHODS OF USING MYT1 INHIBITORS | REPARE THERAPEUTICS INC. (CA) | 2021-10-07 | — | — | WO | disclosed |