Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNPH1 | O43598 | 2/20 | 0.78 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.72 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.72 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | NPY1R | P25929 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NPY2R | P49146 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20277535 | 0.88 | DNPH1 (1.00) | DNPH1P2RX3P2RX2P2RX4LMNA | |
| SCHEMBL20282728 | 0.88 | DNPH1 (1.00) | DNPH1P2RX3P2RX2P2RX4LMNA | |
| SCHEMBL20276972 | 0.88 | DNPH1 (1.00) | DNPH1P2RX3P2RX2P2RX4LMNA | |
| SCHEMBL23907411 | 0.87 | ADORA3 (0.70) | DNPH1P2RX3P2RX2LMNASLC29A1 | |
| SCHEMBL23907386 | 0.87 | NT5E (0.62) | DNPH1ALDH1A1PMP22NPC1RAB9A | |
| SCHEMBL30394947 | 0.86 | DNPH1 (0.81) | DNPH1P2RX3P2RX2P2RX4LMNA | |
| SCHEMBL21839869 | 0.86 | DNPH1 (0.81) | DNPH1P2RX3P2RX2P2RX4LMNA | |
| SCHEMBL23907436 | 0.85 | DNPH1 (0.77) | DNPH1 | |
| SCHEMBL23907409 | 0.85 | DNPH1 (0.64) | DNPH1P2RX3P2RX2P2RX4PMP22 | |
| SCHEMBL23907435 | 0.84 | TAS1R3 (0.72) | PMP22SMN1; SMN2HTTSLC29A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11591355-B2 | CD73 inhibitors and uses thereof | PELOTON THERAPEUTICS INC. (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210317150-A1 | CD73 INHIBITORS AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11591355-B2 | CD73 inhibitors and uses thereof | ENTPD5, ENTPD1, ENTPD3 | DNPH1 1090/4885P2RX3 14/4885P2RX2 17/4885 |
| US-20210317150-A1 | CD73 INHIBITORS AND USES THEREOF | ENTPD5, ENTPD1, NT5E | DNPH1 297/4885P2RX3 37/4885P2RX2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.