Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23908580 | 0.99 | SENP7 (0.62) | SENP7CASP3SENP8SENP6ADORA3 | |
| SCHEMBL21793867 | 0.85 | SENP7 (0.64) | SENP7CASP3SENP8SENP6ADORA3 | |
| SCHEMBL30723192 | 0.84 | KMT2A (0.56) | SENP7CASP3ADORA3TP53RAB9A | |
| SCHEMBL21793861 | 0.84 | KMT2A (0.56) | SENP7CASP3ADORA3TP53RAB9A | |
| SCHEMBL21793707 | 0.84 | SENP7 (0.62) | SENP7CASP3SENP8SENP6ADORA3 | |
| SCHEMBL21793874 | 0.81 | SENP7 (0.58) | SENP7CASP3TP53RAB9ANPC1 | |
| SCHEMBL30723187 | 0.81 | SENP7 (0.58) | SENP7CASP3TP53RAB9ANPC1 | |
| SCHEMBL21793711 | 0.81 | SENP7 (0.57) | SENP7CASP3TP53RAB9ANPC1 | |
| SCHEMBL30723199 | 0.81 | SENP7 (0.57) | SENP7CASP3TP53RAB9ANPC1 | |
| SCHEMBL21793933 | 0.79 | NPC1 (0.49) | TP53RAB9ANPC1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-05-16 | — | — | US | disclosed |
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-12-05 | — | — | US | disclosed |
| EP-4212516-A1 | 2-PHENYL-6-HALO-QUINOXALINE DERIVATIVES AS CHAPERONE-MEDIATED AUTOPHAGY (CMA) MODULATORS FOR THE TREATMENT OF PARKINGSON'S DISEASE | Albert Einstein College of Medicine (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20210317095-A1 | COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | SQSTM1, HSPA5, ATG7 | SENP7 3099/4885CASP3 2834/4885SENP8 2657/4885 |
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | SQSTM1, MCL1, HSPA2 | SENP7 1775/4885CASP3 1753/4885SENP8 1370/4885 |
| US-20210317095-A1 | COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | SQSTM1, HSPA5, ATG7 | SENP7 3099/4885CASP3 2834/4885SENP8 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.