Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20404284 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1ESR1ESR2USP2 | |
| SCHEMBL23912254 | 0.82 | PIK3CD (0.55) | SMN1; SMN2ALDH1A1ESR1ESR2PIK3CD | |
| SCHEMBL20404285 | 0.81 | HDAC1 (0.50) | SMN1; SMN2ALDH1A1ESR1ESR2USP2 | |
| SCHEMBL20404396 | 0.80 | PIK3CD (0.57) | SMN1; SMN2ALDH1A1ESR1ESR2USP2 | |
| SCHEMBL23912237 | 0.79 | HRH3 (0.59) | PIK3CDKCNH2HRH3 | |
| SCHEMBL17458010 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3R1HDAC6 | |
| SCHEMBL16597182 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1ESR1ESR2NPC1 | |
| SCHEMBL16597185 | 0.78 | PDE10A (0.52) | SMN1; SMN2ALDH1A1ESR1ESR2NPC1 | |
| SCHEMBL17235505 | 0.78 | ESR1 (0.60) | SMN1; SMN2ALDH1A1ESR1ESR2USP2 | |
| SCHEMBL23912240 | 0.78 | PIK3CD (0.55) | SMN1; SMN2ALDH1A1PIK3CDLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |