Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23915494 | 0.80 | TRPA1 (0.49) | TRPA1TRPM8TRPV1NOS1DYRK1A | |
| SCHEMBL23914877 | 0.79 | TRPA1 (0.40) | TRPA1TRPM8TRPV1NOS1DYRK1A | |
| SCHEMBL23909011 | 0.75 | TRPA1 (0.53) | TRPA1TRPM8TRPV1CNR2NOS1 | |
| SCHEMBL29109556 | 0.74 | AXL (0.60) | TRPA1TRPM8TRPV1NOS1DYRK1A | |
| SCHEMBL23915491 | 0.74 | TRPA1 (0.52) | TRPA1NOS1DYRK1AAXLCHEK1 | |
| SCHEMBL25346085 | 0.74 | METAP2 (0.46) | TRPA1TRPM8TRPV1METAP2NOS1 | |
| SCHEMBL25344307 | 0.73 | METAP2 (0.57) | TRPA1METAP2NOS1DYRK1AAXL | |
| SCHEMBL28814958 | 0.73 | MEN1 (0.48) | TRPA1TRPM8METAP2NOS1KDM4E | |
| SCHEMBL3590783 | 0.71 | NOS1 (0.57) | TRPA1TRPM8TRPV1METAP2NOS1 | |
| SCHEMBL24358709 | 0.71 | AXL (0.48) | TRPA1TRPM8NOS1DYRK1AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GILEAD SCIENCES, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | S1PR1, S1PR3, S1PR2 | TRPA1 656/4885TRPM8 1596/4885TRPV1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.