Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 11/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258375 | 0.85 | CACNA1I (0.46) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL14768720 | 0.82 | GNAI3 (0.38) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL10246565 | 0.82 | GNAI3 (0.38) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL21214167 | 0.82 | GNAI3 (0.51) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL19248417 | 0.81 | CACNA1I (0.51) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL14614920 | 0.81 | GNAO1 (0.47) | KCNH2GNAO1GNAI3GNAI1EPHX1 | |
| SCHEMBL10245112 | 0.79 | EPHX1 (0.41) | CACNA1IKCNH2GNAO1GNAI3GNAI1 | |
| SCHEMBL4569282 | 0.79 | NCF1 (0.46) | GNAO1GNAI3GNAI1 | |
| SCHEMBL23919061 | 0.79 | CACNA1I (0.44) | CACNA1IKCNH2GNAO1OPRM1OPRL1 | |
| SCHEMBL19958952 | 0.78 | KCNH2 (0.52) | CACNA1IKCNH2GNAO1GNAI3GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230097358-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2023-03-30 | — | — | US | disclosed |
| US-20210315896-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315896-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | LRRK2, CRBN, MDM2 | CACNA1I 4058/4885KCNH2 4503/4885GNAO1 2111/4885 |
| US-20230097358-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | LRRK2, CRBN, MDM2 | CACNA1I 4058/4885KCNH2 4503/4885GNAO1 2111/4885 |
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | LRRK2, ADRM1, CRBN | CACNA1I 4452/4885KCNH2 4712/4885GNAO1 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.