Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23074859 | 0.78 | CYP2A6 (0.59) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL28423964 | 0.77 | CA2 (0.46) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL26522334 | 0.77 | MCL1 (0.53) | CA2CYP1A2GABRA1GABRB2ALDH1A1 | |
| SCHEMBL26522361 | 0.77 | CYP2A6 (0.43) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL13433295 | 0.77 | CYP2A6 (0.43) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL27117088 | 0.77 | CYP1A2 (0.43) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL21085332 | 0.77 | CA2 (0.39) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL29972825 | 0.74 | KIF11 (0.48) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL4818310 | 0.74 | KIF11 (0.48) | CA2CYP2A6CYP1A2GABRA1GABRB2 | |
| SCHEMBL252402 | 0.74 | KIF11 (0.48) | CA2CYP2A6CYP1A2GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149020-B2 | MAP kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11149020-B2 | MAP kinase modulators and uses thereof | MAPK1, MAP3K1, MAP3K2 | CA2 3980/4885CYP2A6 4660/4885CYP1A2 4173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.