Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949354 | 0.86 | CHRM2 (0.47) | KMT2AKDM4EALDH1A1CHRM2CHRM1 | |
| SCHEMBL465791 | 0.86 | CHRM2 (0.47) | KDM4EALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL16061780 | 0.86 | FAAH (0.58) | KDM4EALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL25282066 | 0.85 | CHRM4 (0.46) | KDM4EALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL22769224 | 0.84 | CHRM2 (0.46) | GRM5KDM4EALDH1A1CHRM2CHRM1 | |
| SCHEMBL22166944 | 0.83 | ACHE (0.48) | KDM4EALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL19013075 | 0.83 | GRM5 (0.45) | GRM5KDM4EALDH1A1CHRM2CHRM1 | |
| SCHEMBL31731787 | 0.83 | GRM5 (0.45) | GRM5KDM4EALDH1A1CHRM2CHRM1 | |
| SCHEMBL24384168 | 0.82 | ALDH1A1 (0.47) | KMT2AKDM4EALDH1A1CHRM2CHRM1 | |
| SCHEMBL31192689 | 0.81 | KDM4E (0.52) | GRM5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |