Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250899 | 0.75 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL20731975 | 0.74 | HTT (0.41) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL8250693 | 0.69 | ADRB1 (0.44) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL6582872 | 0.69 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL658998 | 0.69 | HRH3 (0.43) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL20731201 | 0.69 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAGAAADRB1 | |
| SCHEMBL30059728 | 0.68 | MAPT (0.50) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL8070794 | 0.68 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL11295489 | 0.66 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL28943954 | 0.66 | MAPT (0.45) | ALDH1A1MAPTLMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | USP28, USP25, USP24 | ALDH1A1 2167/4885MAPT 2661/4885LMNA 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.