Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548147 | 0.83 | LMNA (0.52) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL548161 | 0.77 | LMNA (0.50) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL31415807 | 0.75 | LMNA (0.48) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL547607 | 0.75 | LMNA (0.48) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL6764461 | 0.75 | MEN1 (0.43) | THRBLMNAMEN1BLMKMT2A | |
| SCHEMBL7792621 | 0.75 | LMNA (0.43) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL12212996 | 0.75 | LMNA (0.43) | HTR2CTHRBLMNAMEN1BLM | |
| SCHEMBL28958240 | 0.74 | ALDH1A1 (0.43) | HTR2CTHRBLMNATSHRALDH1A1 | |
| SCHEMBL28956588 | 0.74 | HTR2C (0.35) | HTR2CTHRBLMNATSHRHCAR1 | |
| SCHEMBL2913532 | 0.74 | HTR2C (0.44) | HTR2CTHRBLMNATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4136084-A1 | BCL-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021208963-A1 | BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-10-21 | — | — | WO | disclosed |