Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588229 | 0.85 | KDM4E (0.46) | L3MBTL1KDM4EPDE4DMEN1ALDH1A1 | |
| SCHEMBL2588944 | 0.82 | PDE4D (0.40) | L3MBTL1KDM4EPDE4DMEN1ALDH1A1 | |
| SCHEMBL20605030 | 0.80 | CNR2 (0.38) | L3MBTL1KDM4EPDE4DMEN1ALDH1A1 | |
| SCHEMBL23289666 | 0.79 | KDM4E (0.38) | NOTUMSOS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL30241579 | 0.78 | CYP46A1 (0.38) | KDM4EMETAP2MEN1ALDH1A1KMT2A | |
| SCHEMBL23925044 | 0.78 | CYP46A1 (0.38) | KDM4EMETAP2MEN1ALDH1A1KMT2A | |
| SCHEMBL17113166 | 0.78 | L3MBTL1 (0.44) | L3MBTL1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL20604777 | 0.76 | SMN1; SMN2 (0.47) | KDM4EMEN1ALDH1A1KMT2AOPRK1 | |
| SCHEMBL2589630 | 0.74 | L3MBTL1 (0.41) | L3MBTL1KDM4ENR4A2OPRK1TSHR | |
| SCHEMBL28899593 | 0.74 | L3MBTL1 (0.39) | L3MBTL1NOTUMKDM4EALDH1A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192623-A1 | Indazole Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-06-22 | — | — | US | disclosed |
| EP-4136074-A1 | INDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021209481-A1 | INDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192623-A1 | Indazole Derivatives | CYP3A43, CYP1A2, CYP3A7 | L3MBTL1 3232/4885NOTUM 2440/4885SOS1 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.