Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26631562 | 0.82 | PTGES (0.40) | DHODHALDH1A1KDM4EMAPTPTGES | |
| SCHEMBL30139028 | 0.82 | PTGES (0.40) | DHODHALDH1A1KDM4EMAPTPTGES | |
| SCHEMBL26631528 | 0.80 | RNASEH1 (0.43) | RNASEH1DHODHBRD4CREBBPPTGES | |
| SCHEMBL30138979 | 0.80 | RNASEH1 (0.43) | RNASEH1DHODHBRD4CREBBPPTGES | |
| SCHEMBL20482842 | 0.79 | DHODH (0.44) | DHODHMAPT | |
| SCHEMBL30242145 | 0.79 | DHODH (0.44) | DHODHMAPT | |
| SCHEMBL26631541 | 0.75 | DHODH (0.38) | DHODHALDH1A1KDM4EHPGDCRHBP | |
| SCHEMBL30139014 | 0.75 | DHODH (0.38) | DHODHALDH1A1KDM4EHPGDCRHBP | |
| SCHEMBL18152681 | 0.74 | GRIN1 (0.47) | BRD4ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL20477252 | 0.74 | RNASEH1 (0.68) | RNASEH1ALDH1A1TSHRGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348398-A1 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-11-02 | — | — | US | disclosed |
| EP-4136077-A1 | BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-02-22 | — | — | EP | disclosed |
| CN-115485266-A | Benzimidazole derivatives | 豪夫迈·罗氏有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2021209484-A1 | BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348398-A1 | Benzimidazole derivatives | HRH4, H1-4, CYP3A4 | RNASEH1 1006/4885DHODH 976/4885BRD4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.