Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.67 |
| ▸ | SPR | P35270 | 1/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23925476 | 0.84 | MAPT (0.76) | MAPTSMN1; SMN2MEN1KMT2AMTNR1A | |
| SCHEMBL23925614 | 0.81 | MAPT (0.80) | MAPTSMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL23925774 | 0.80 | MEN1 (0.62) | MAPTSMN1; SMN2MEN1KMT2AMTNR1A | |
| SCHEMBL23925499 | 0.80 | MAPT (0.68) | MAPTSMN1; SMN2MEN1KMT2AMTNR1A | |
| SCHEMBL4512654 | 0.79 | MTNR1A (1.00) | MAPTMEN1KMT2AMTNR1ASPR | |
| SCHEMBL6347047 | 0.79 | MAPT (0.61) | MAPTSMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL12720806 | 0.79 | SPR (1.00) | MAPTMEN1KMT2AMTNR1ASPR | |
| SCHEMBL8802650 | 0.78 | SPR (0.61) | MAPTSMN1; SMN2MEN1KMT2AMTNR1A | |
| SCHEMBL30578783 | 0.78 | MAPT (0.75) | MAPTSMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL23925547 | 0.78 | MAPT (0.78) | MAPTSMN1; SMN2TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | claimed |
| WO-2021211123-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-10-21 | — | — | WO | claimed |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | disclosed |
| WO-2021211123-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | TLR4, TLR5, TLR1 | MAPT 1718/4885SMN1; SMN2 4580/4885TP53 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.