Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638544 | 0.92 | OPRM1 (0.45) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL9873557 | 0.91 | OPRM1 (0.41) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL10700915 | 0.86 | KCNA5 (0.50) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL2450850 | 0.86 | ALDH1A1 (0.44) | OPRM1TRPM8KCNA5TRPV1ALDH1A1 | |
| SCHEMBL5824341 | 0.86 | OPRM1 (0.47) | OPRM1TRPM8TRPA1KCNA5ALDH1A1 | |
| SCHEMBL9698663 | 0.85 | OPRM1 (0.50) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL29842792 | 0.84 | OPRM1 (0.48) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL348141 | 0.82 | OPRM1 (0.44) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL8498802 | 0.81 | KCNA5 (0.46) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL31546067 | 0.81 | OPRM1 (0.58) | OPRM1TRPM8TRPA1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |
| EP-0026204-A1 | PROCESS FOR THE PRODUCTION OF ALKALI METAL-CELLULOSE-SILICATES AND THEIR REACTION PRODUCTS | BLOUNT, David H. (US) | 1981-04-08 | — | — | EP | disclosed |
| WO-1980002142-A1 | PROCESS FOR THE PRODUCTION OF ALKALI METAL-CELLULOSE-SILICATES AND THEIR REACTION PRODUCTS | BLOUNT D (US) | 1980-10-16 | — | — | WO | disclosed |