Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700915 | 0.90 | KCNA5 (0.50) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL5824341 | 0.83 | OPRM1 (0.47) | KCNA5ALDH1A1LMNAHTR2CHTR2A | |
| SCHEMBL8336802 | 0.83 | KCNA5 (0.44) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL16191316 | 0.81 | HTR2C (0.47) | ALDH1A1HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL2392586 | 0.81 | OPRM1 (0.45) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL7540738 | 0.80 | KDM1A (0.49) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL17847282 | 0.80 | HTR2C (0.46) | KCNA5ALDH1A1LMNAHTR2CHTR2A | |
| SCHEMBL30506638 | 0.80 | HTR2C (0.46) | KCNA5ALDH1A1LMNAHTR2CHTR2A | |
| SCHEMBL28635808 | 0.80 | TRPM8 (0.46) | KCNA5ALDH1A1LMNAHTR2CTRPM8 | |
| SCHEMBL4466623 | 0.80 | KCNA5 (0.38) | KCNA5ALDH1A1LMNATRPM8TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898564-A1 | METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS | Merck & Co., Inc. (US) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997038976-A1 | METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |