SCHEMBL23926512

SCHEMBL23926512

O=c1sc2cc([N+](=O)[O-])ccc2n1C(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDYL2 Q8N8U2 2/20 0.47
CDYL Q9Y232 2/20 0.47
CBX7 O95931 1/20 0.42
CDY1; CDY1B Q9Y6F8 1/20 0.42
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP1A2 P05177 1/20 0.39
HTT P42858 1/20 0.39
PDK1 Q15118 1/20 0.38
PHOSPHO1 Q8TCT1 1/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.37
APOBEC3A P31941 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3034372 0.85 KMT2A (0.52) CDYL2CDYLCBX7CDY1; CDY1BCRHBP
SCHEMBL23926489 0.78 CDYL2 (0.43) CDYL2CDYLCBX7CDY1; CDY1BKMT2A
SCHEMBL3032939 0.77 RAB9A (0.51) CDYL2CDYLCBX7CDY1; CDY1BCRHBP
SCHEMBL23926488 0.75 CYP1A2 (0.50) KMT2AMEN1ALDH1A1CYP3A4TSHR
SCHEMBL3032915 0.73 CYP1A2 (0.60) CDYL2CDYLCBX7CDY1; CDY1BCRHBP
SCHEMBL15712481 0.73 CDYL2 (0.53) CDYL2CDYLCBX7CDY1; CDY1BCRHBP
SCHEMBL10933312 0.72 CDYL2 (0.49) CDYL2CDYLCBX7CDY1; CDY1BKMT2A
SCHEMBL23926471 0.71 IDO1 (0.43) KMT2AMEN1ALDH1A1CYP1A2PTPRC
SCHEMBL30349844 0.71 CYP1A2 (0.49) KMT2AMEN1SMN1; SMN2ALDH1A1TSHR
SCHEMBL15712229 0.70 KDM4E (0.61) CDYL2CDYLCBX7CDY1; CDY1BKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-31 US disclosed
CN-113727972-B Novel hydrazone derivatives having terminal amine groups substituted with aryl or heteroaryl groups and use thereof 韩国科学技术研究院 2024-12-27 CN disclosed
CN-115867277-A Novel fused heterocyclyl-carbohydrazone acyldinitrile compounds and use thereof 韩国科学技术研究院 2023-03-28 CN disclosed
US-20220396553-A1 NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2022-12-15 US disclosed
EP-3901139-A1 NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF Korea Institute of Science and Technology (KR) 2021-10-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof ABL1, TH, CYP3A43 CDYL2 1535/4885CDYL 867/4885CBX7 2341/4885
US-20220396553-A1 NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF AANAT, NAT1, HNMT CDYL2 992/4885CDYL 722/4885CBX7 1507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.