Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23928672 | 0.86 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL23928507 | 0.83 | PTGS2 (0.51) | ALDH1A1SMN1; SMN2HPGDKDM4EMEN1 | |
| SCHEMBL23928488 | 0.83 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL23928662 | 0.82 | MAPT (0.55) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL22111346 | 0.80 | MEN1 (0.55) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL30963700 | 0.80 | L3MBTL1 (0.74) | ALDH1A1L3MBTL1HPGDATMCA12 | |
| SCHEMBL23928481 | 0.79 | AURKA (0.57) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL23928500 | 0.79 | CA12 (0.73) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL29333627 | 0.72 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E | |
| SCHEMBL6678606 | 0.70 | KDM4E (0.69) | ALDH1A1SMN1; SMN2L3MBTL1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548875-B2 | Inhibitor compounds for male contraception | UNIVERSITY OF WASHINGTON (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | UNIVERSITY OF WASHINGTON (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | ALDH1A1, ALDH3A1, ALDH16A1 | ALDH1A1 1/4885SMN1; SMN2 2873/4885L3MBTL1 4048/4885 |
| US-11548875-B2 | Inhibitor compounds for male contraception | ALDH1A1, ALDH3A1, ALDH16A1 | ALDH1A1 1/4885SMN1; SMN2 2873/4885L3MBTL1 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.