Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 1.00 |
| ▸ | THRB | P10828 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.71 |
| ▸ | MEN1 | O00255 | 11/20 | 0.71 |
| ▸ | GAA | P10253 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | GFER | P55789 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13576573 | 0.89 | MAPT (0.88) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL10172988 | 0.82 | MAPT (0.77) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL22095307 | 0.82 | MAPT (0.76) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL23928590 | 0.82 | MAPT (0.76) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL9790530 | 0.82 | KMT2A (0.76) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL22095308 | 0.82 | MAPT (0.76) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL23928537 | 0.80 | MAPT (0.67) | MAPTTHRBKMT2AGAAALDH1A1 | |
| SCHEMBL15217655 | 0.80 | MAPT (0.72) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL23928657 | 0.79 | MAPT (0.64) | MAPTTHRBKMT2AMEN1GAA | |
| SCHEMBL12670654 | 0.79 | MAPT (0.64) | MAPTTHRBKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548875-B2 | Inhibitor compounds for male contraception | UNIVERSITY OF WASHINGTON (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | UNIVERSITY OF WASHINGTON (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | ALDH1A1, ALDH3A1, ALDH16A1 | MAPT 4083/4885THRB 3666/4885KMT2A 1384/4885 |
| US-11548875-B2 | Inhibitor compounds for male contraception | ALDH1A1, ALDH3A1, ALDH16A1 | MAPT 4083/4885THRB 3666/4885KMT2A 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.