SCHEMBL23928706

SCHEMBL23928706

COC(=O)c1cnc2c(c1)ncn2-c1cccc(Br)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 3/20 0.51
HPGD P15428 4/20 0.49
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
MAPT P10636 1/20 0.45
RAB9A P51151 1/20 0.45
POLB P06746 1/20 0.44
ALDH1A1 P00352 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SRC P12931 1/20 0.41
GAK O14976 1/20 0.41
TP53 P04637 1/20 0.40
PDE4A P27815 1/20 0.39
KCNH2 Q12809 1/20 0.39
PSMD14 O00487 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30509794 1.00 FGFR1 (0.51) FGFR1HPGDMEN1KMT2AMAPT
SCHEMBL23675171 0.87 HPGD (0.64) FGFR1HPGDMAPTRAB9AALDH1A1
SCHEMBL29244153 0.87 HPGD (0.52) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL31022748 0.87 HPGD (0.52) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL31022762 0.85 HPGD (0.53) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL29026031 0.85 HPGD (0.53) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL29244257 0.84 HPGD (0.46) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL6875300 0.82 FGFR1 (0.76) FGFR1HPGDMAPTRAB9AALDH1A1
SCHEMBL29244198 0.82 HPGD (0.47) FGFR1HPGDMEN1KMT2APOLB
SCHEMBL13202022 0.81 HPGD (0.55) FGFR1HPGDMAPTRAB9ASRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118290419-A Pyridoimidazole derivative, preparation method and application thereof 成都硕德药业有限公司 2024-07-05 CN disclosed
CN-112714765-B GABA A Receptor ligands 萨尼奥纳有限责任公司 2023-06-30 CN disclosed
EP-3849976-B1 A GABA A RECEPTOR LIGAND SANIONA AS (DK) 2022-10-26 EP disclosed
US-11396510-B2 GABAA receptor ligand SANIONA A/S (DK) 2022-07-26 US disclosed
US-20210332042-A1 A GABAA Receptor Ligand SANIONA A/S (DK) 2021-10-28 US disclosed
CN-112714765-A GABAAReceptor ligands 萨尼奥纳有限责任公司 2021-04-27 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210332042-A1 A GABAA Receptor Ligand GABRA2, GABRA6, GABRA5 FGFR1 2537/4885HPGD 2190/4885MEN1 4768/4885
US-11396510-B2 GABAA receptor ligand GABRA2, GABRA3, GABRA6 FGFR1 2518/4885HPGD 1982/4885MEN1 4729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.