Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 18/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30587447 | 1.00 | CHRNA7 (0.57) | CHRNA7TRPV1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8047542 | 0.85 | BRD4 (0.44) | CHRNA7KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23928858 | 0.81 | CHRNA7 (0.64) | CHRNA7TRPV1KDM4E | |
| SCHEMBL13837417 | 0.80 | BRD9 (0.47) | KDM4E | |
| SCHEMBL17653861 | 0.80 | CACNA1H (0.46) | CHRNA7 | |
| SCHEMBL29269258 | 0.80 | CACNA1H (0.50) | TRPV1KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL31035896 | 0.79 | CHRNA7 (0.58) | CHRNA7TRPV1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10165151 | 0.78 | POLB (0.52) | KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL20946419 | 0.78 | GAA (0.46) | KDM4E | |
| SCHEMBL3180689 | 0.77 | L3MBTL1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820869-B1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2023-08-30 | — | — | EP | disclosed |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
| CN-112823157-A | Spirochroman derivatives | 吉瑞工厂 | 2021-05-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | CHRNA7 1/4885TRPV1 177/4885KDM4E 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.