Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Racemethionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.50 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL291985 | 1.00 | BHMT (0.50) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL291986 | 1.00 | BHMT (0.50) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL9192308 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL9190291 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL28118990 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL9192305 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL8463168 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL29172847 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL1764849 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL7781670 | 0.96 | RNPEP (0.50) | BHMTPMP22BHMT2RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4138828-A1 | ORAL COMPOSITION COMPRISING S-ADENOSYL METHIONINE AND A PROBIOTIC AND ITS USE FOR TREATING AND/OR PREVENTING MOOD DISORDERS | MONTEFARMACO OTC S.p.A. (IT) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021214661-A1 | ORAL COMPOSITION COMPRISING S-ADENOSYL METHIONINE AND A PROBIOTIC AND ITS USE FOR TREATING AND/OR PREVENTING MOOD DISORDERS | MONTEFARMACO OTC S.P.A. (IT) | 2021-10-28 | — | — | WO | disclosed |