Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.50 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL291985 | 1.00 | BHMT (0.50) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL23930380 | 1.00 | BHMT (0.50) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL9192308 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL9190291 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL28118990 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL9192305 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL8463168 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Racemethionine SCHEMBL29172847 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL1764849 | 0.98 | BHMT (0.49) | BHMTPMP22BHMT2RNPEPNOS2 | |
| Methionine SCHEMBL7781670 | 0.96 | RNPEP (0.50) | BHMTPMP22BHMT2RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106798157-A | A kind of fleshy duck fodder of rice-type and preparation method thereof | 广东温氏食品集团股份有限公司 | 2017-06-06 | — | — | CN | claimed |
| US-9534010-B2 | Stable indole-3-propionate salts of S-adenosyl-L-methionine | HEBERT SAM-E LLC | 2017-01-03 | — | — | US | claimed |
| CN-1935825-A | Method for preparing S-adenosine-L-methionine sulfate | UNIV ZHEJIANG (CN) | 2007-03-28 | — | — | CN | claimed |
| CN-1135297-A | Application of methionine sulfate metal matches in bullog cultivation | HUNAN CHEMICAL ACADEMY (CN) | 1996-11-13 | — | — | CN | claimed |
| US-20260034169-A1 | STABILISED SILICIC ACID SOLUTIONS | BARLAA B.V. (NL) | 2026-02-05 | — | — | US | disclosed |
| EP-4565530-A1 | STABILISED SILICIC ACID SOLUTIONS | Barlaa B.V. (NL) | 2025-06-11 | — | — | EP | disclosed |
| EP-4302829-B1 | PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION | STEALTH BIOTHERAPEUTICS INC (US) | 2025-05-21 | — | — | EP | disclosed |
| CN-119894823-A | Stable silicic acid solutions | 巴尔拉有限公司 | 2025-04-25 | — | — | CN | disclosed |
| US-12137716-B2 | Methods of liver disease treatment | HUDNALL MICHAEL (US) | 2024-11-12 | — | — | US | disclosed |
| EP-4417620-A1 | METHOD FOR PRODUCING ANTIBODY POPULATION | Prestige Biologics Co., Ltd. (KR) | 2024-08-21 | — | — | EP | disclosed |
| US-20240254534-A1 | METHOD FOR PRODUCING ANTIBODY POPULATION | PRESTIGE BIOLOGICS CO., LTD. (KR) | 2024-08-01 | — | — | US | disclosed |
| CN-118369337-A | Method for producing antibody population | 普莱斯蒂生物制品有限公司 | 2024-07-19 | — | — | CN | disclosed |
| EP-0844239-A1 | Method for producing homocystine | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5670549-A | Prevention and amelioration of liver toxicity with beta-carotene | EPITEK, INC. | 1997-09-23 | — | — | US | disclosed |
| CN-1135297-A | Application of methionine sulfate metal matches in bullog cultivation | HUNAN CHEMICAL ACADEMY (CN) | 1996-11-13 | — | — | CN | disclosed |
| CN-1135297-A | Application of methionine sulfate metal matches in bullog cultivation | HUNAN CHEMICAL ACADEMY (CN) | 1996-11-13 | — | — | CN | disclosed |
| WO-1994010992-A1 | PREVENTION AND AMELIORATION OF ACETAMINOPHEN TOXICITY WITH BETA-CAROTENE | BARANOWITZ STEVEN A (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5260340-A | Prevention and amelioration of acetaminophen toxicity with beta-carotene | EPITEK, INC. | 1993-11-09 | — | — | US | disclosed |
| EP-0419238-A1 | Antibodies and proteins | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-03-27 | — | — | EP | disclosed |
| US-4067994-A | FEED SUPPLEMENTS | ZINPRO CORPORATION (US) | 1978-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260034169-A1 | STABILISED SILICIC ACID SOLUTIONS | HAO2, SMS, SSTR2 | BHMT 1835/4885PMP22 3841/4885BHMT2 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.