Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825471 | 0.87 | RAB9A (0.50) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2825470 | 0.86 | RAB9A (0.49) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL23930834 | 0.86 | ALOX15 (0.47) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL10288449 | 0.82 | ALDH1A1 (0.58) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL2827620 | 0.82 | SMN1; SMN2 (0.49) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL2824661 | 0.81 | SMN1; SMN2 (0.48) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL13141309 | 0.78 | SMN1; SMN2 (0.46) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL2825380 | 0.78 | SMN1; SMN2 (0.46) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL2824616 | 0.75 | SMN1; SMN2 (0.43) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 | |
| SCHEMBL21879981 | 0.73 | RAB9A (0.46) | KMT2ARAB9AMEN1ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215545-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |