Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827620 | 0.86 | SMN1; SMN2 (0.49) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL2825471 | 0.85 | RAB9A (0.50) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL2824661 | 0.85 | SMN1; SMN2 (0.48) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL23930834 | 0.83 | ALOX15 (0.47) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2825470 | 0.83 | RAB9A (0.49) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL13141309 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL2825380 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL23930934 | 0.82 | KMT2A (0.48) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL14038235 | 0.80 | ALOX15 (0.55) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 | |
| SCHEMBL6598308 | 0.80 | ALOX15 (0.55) | ALDH1A1ALOX15NPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093264-B2 | Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC. (CA) | 2012-01-10 | — | — | US | disclosed |
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | METHYLGENE, INC. (CA) | 2008-01-03 | — | — | US | disclosed |
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE, INC. | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | HGF, MET, FLT1 | ALDH1A1 1649/4885ALOX15 3556/4885NPSR1 565/4885 |
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | HGF, ERBB2, MET | ALDH1A1 3139/4885ALOX15 4095/4885NPSR1 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.