SCHEMBL23932507

SCHEMBL23932507

Cc1ncnc(N2CCN(Cc3nc4ccc(C(F)(F)F)cc4o3)CC2)c1C

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RPS6KB1 P23443 2/20 0.44
LMNA P02545 2/20 0.42
HRH4 Q9H3N8 2/20 0.41
TP53 P04637 2/20 0.40
RBP4 P02753 1/20 0.40
SOS1 Q07889 1/20 0.40
GRM2 Q14416 1/20 0.38
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CACNA1G O43497 1/20 0.37
KCNH2 Q12809 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MAPT P10636 1/20 0.37
PIK3CA P42336 1/20 0.37
MTOR P42345 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30040088 1.00 RPS6KB1 (0.44) RPS6KB1LMNAHRH4TP53RBP4
SCHEMBL23932502 0.93 RPS6KB1 (0.42) RPS6KB1LMNAHRH4TP53RBP4
SCHEMBL30040810 0.93 RPS6KB1 (0.42) RPS6KB1LMNAHRH4TP53RBP4
SCHEMBL31738151 0.89 TP53 (0.41) RPS6KB1LMNATP53SOS1ALDH1A1
SCHEMBL23932567 0.87 HTT (0.47) LMNATP53SOS1ALDH1A1HTT
SCHEMBL30041055 0.87 HTT (0.47) LMNATP53SOS1ALDH1A1HTT
SCHEMBL25510924 0.87 LMNA (0.55) LMNATP53SOS1SMN1; SMN2CACNA1G
SCHEMBL23932566 0.85 SOS1 (0.57) RPS6KB1LMNAHRH4TP53SOS1
SCHEMBL31737718 0.85 LMNA (0.44) LMNATP53SOS1SMN1; SMN2PIK3CA
SCHEMBL31737700 0.85 TP53 (0.44) LMNATP53SOS1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
EP-4139291-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2023-03-01 EP disclosed
CN-115427404-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-12-02 CN disclosed
WO-2021216665-A9 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-12-02 WO disclosed
WO-2021216665-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-10-28 WO disclosed
WO-2021216665-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF COL1A1, COL2A1, COL14A1 RPS6KB1 316/4885LMNA 575/4885HRH4 4471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.