Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23934344 | 0.87 | THRB (0.38) | THRBMAPTPOLBLMNAALDH1A1 | |
| SCHEMBL23934731 | 0.84 | — | — | |
| SCHEMBL23934596 | 0.83 | — | — | |
| SCHEMBL23934587 | 0.83 | KMT2A (0.39) | THRBLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL23934681 | 0.83 | ALDH1A1 (0.33) | MAPTLMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL23934328 | 0.81 | THRB (0.34) | THRBMAPTPOLBLMNAALDH1A1 | |
| SCHEMBL23739521 | 0.81 | POLB (0.35) | THRBMAPTPOLBLMNAALDH1A1 | |
| SCHEMBL24572202 | 0.80 | POLB (0.35) | THRBMAPTPOLBLMNAALDH1A1 | |
| SCHEMBL23739667 | 0.80 | POLB (0.35) | THRBMAPTPOLBLMNAALDH1A1 | |
| SCHEMBL23739890 | 0.78 | POLB (0.35) | THRBMAPTPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896062-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-10-20 | — | — | EP | disclosed |