Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742208 | 1.00 | BACE1 (0.45) | BACE1EPHX2SCN4AEGFRNOS3 | |
| SCHEMBL436530 | 0.83 | BACE1 (0.42) | BACE1EPHX2SCN4AEGFRNOS3 | |
| SCHEMBL439770 | 0.83 | BACE1 (0.42) | BACE1EPHX2SCN4AEGFRNOS3 | |
| SCHEMBL9169732 | 0.79 | ESR1 (0.47) | NPBWR1CCNCCDK8ALDH1A1KDM4E | |
| SCHEMBL439948 | 0.79 | ALDH1A1 (0.53) | FEN1ALOX5APKDRCDK2CHEK1 | |
| SCHEMBL18658922 | 0.77 | ALDH1A1 (0.47) | BACE1ALDH1A1KDM4EHPGD | |
| SCHEMBL5314200 | 0.77 | NR4A2 (0.56) | BACE1EPHX2SCN4AEGFRNOS3 | |
| SCHEMBL10385174 | 0.77 | BCHE (0.45) | BACE1CCNCCDK8MAP4K4AXL | |
| SCHEMBL28240867 | 0.76 | PARP1 (0.46) | EGFRRPS6KA3CSNK2A1DYRK1AALDH1A1 | |
| SCHEMBL29728013 | 0.74 | MAP4K4 (0.54) | EGFRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3592741-B1 | NOVEL IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2023-02-15 | — | — | EP | disclosed |
| CN-111051304-B | Imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2022-12-27 | — | — | CN | disclosed |
| CN-111201226-B | Cyclic substituted imidazo [4,5-c ] quinoline derivatives | 辉瑞大药厂 | 2022-07-22 | — | — | CN | disclosed |
| EP-3592740-B1 | CYCLIC SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES | PFIZER (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |
| CN-108137586-B | Novel imidazo [4,5-c ] quinoline and imidazo [4,5-c ] [1,5] naphthyridine derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2021-04-13 | — | — | CN | disclosed |
| CN-111201226-A | Cyclic substituted imidazo [4,5-c ] quinoline derivatives | 辉瑞大药厂 | 2020-05-26 | — | — | CN | disclosed |
| CN-111051304-A | Novel imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2020-04-21 | — | — | CN | disclosed |