SCHEMBL23935701

SCHEMBL23935701

C=C(NC)c1ccc(CC)cc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 3/20 0.42
TRPA1 O75762 1/20 0.38
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
RAPGEF4 Q8WZA2 1/20 0.36
ALOX5 P09917 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
PDE2A O00408 1/20 0.34
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
SRD5A2 P31213 1/20 0.33
NR1H4 Q96RI1 1/20 0.33
EGFR P00533 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
AGTR1 P30556 1/20 0.33
PKM P14618 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20195153 0.81 GAA (0.39) PLK1TRPA1ALDH1A1CYP1A2CYP2A6
SCHEMBL19415763 0.79 TRPA1 (0.42) PLK1TRPA1ESR1ESR2RAPGEF4
SCHEMBL4518402 0.79 PLK1 (0.59) PLK1ALDH1A1NR1H4EGFRGAA
SCHEMBL20219212 0.78 TRPA1 (0.41) PLK1TRPA1ESR1ESR2RAPGEF4
SCHEMBL20194393 0.77 TRPA1 (0.34) PLK1TRPA1ESR1ESR2RAPGEF4
SCHEMBL19248818 0.77 L3MBTL1 (0.42) ALDH1A1SMN1; SMN2RARB
SCHEMBL19311402 0.75 TRPA1 (0.38) TRPA1ESR1ESR2RAPGEF4ALOX5
SCHEMBL23220912 0.75 TRPA1 (0.38) PLK1TRPA1ESR1ESR2RAPGEF4
SCHEMBL20220178 0.75 PLK1 (0.59) PLK1ALDH1A1CYP2A6GAAMAPT
SCHEMBL5502090 0.73 ALDH1A1 (0.49) PLK1ALDH1A1GAAMAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3896056-A1 AMINO ACID HAVING FUNCTIONAL GROUP CAPABLE OF INTERMOLECULAR HYDROGEN BONDING, PEPTIDE COMPOUND CONTAINING SAME AND METHOD FOR PRODUCTION THEREOF CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-10-20 EP disclosed