Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390990 | 0.84 | CYP3A4 (0.39) | LMNAMEN1KMT2AAVPR1AOPRM1 | |
| SCHEMBL2388730 | 0.81 | OPRM1 (0.36) | LMNAMEN1KMT2AAVPR1AOPRM1 | |
| SCHEMBL2394397 | 0.81 | OPRM1 (0.36) | LMNAMEN1KMT2AAVPR1AOPRM1 | |
| SCHEMBL23458984 | 0.72 | ALDH1A1 (0.42) | LMNAMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL23458987 | 0.72 | ALDH1A1 (0.42) | LMNAMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL28485250 | 0.70 | ALDH1A1 (0.42) | LMNAMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL2388729 | 0.69 | SMN1; SMN2 (0.47) | LMNAKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL2993414 | 0.68 | LMNA (0.40) | LMNAMEN1KMT2AAVPR1AOPRM1 | |
| SCHEMBL1420940 | 0.68 | AGTR2 (0.40) | — | |
| SCHEMBL2390647 | 0.68 | SMN1; SMN2 (0.45) | LMNAKDM4EMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013008-B2 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-09-06 | — | — | US | disclosed |