Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20673875 | 0.82 | LMNA (0.43) | ALDH1A1KMT2AMEN1MAPK1NR4A2 | |
| SCHEMBL11557695 | 0.79 | LMNA (0.52) | ALDH1A1KMT2AMEN1BRD4HSD17B10 | |
| SCHEMBL21958623 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL20673904 | 0.75 | MAP2K2 (0.41) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL28070206 | 0.71 | NR4A2 (0.68) | ALDH1A1KMT2ANR4A2CNR1BRCA1 | |
| SCHEMBL11664740 | 0.68 | LMNA (0.44) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL28131233 | 0.68 | ICMT (0.55) | ALDH1A1KMT2AMAPTNR4A2MAP2K2 | |
| SCHEMBL10193361 | 0.68 | CNR1 (0.46) | ALDH1A1KMT2AMEN1NR4A2MAP2K2 | |
| SCHEMBL21958624 | 0.67 | BRD4 (0.38) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL8513279 | 0.67 | CNR1 (0.51) | ALDH1A1CNR1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |