Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937714 | 0.85 | METAP2 (0.48) | KDM4EALDH1A1GAAGLAMETAP2 | |
| SCHEMBL23937954 | 0.81 | METAP2 (0.45) | KDM4EALDH1A1GAAGLAMETAP2 | |
| SCHEMBL10211144 | 0.77 | CNR1 (0.42) | METAP2PKMRAB9ACNR1CNR2 | |
| SCHEMBL28277678 | 0.77 | CNR1 (0.42) | KDM4EALDH1A1METAP2PLK1RAB9A | |
| SCHEMBL8876740 | 0.75 | PLK1 (0.43) | KDM4EALDH1A1GAAPLK1RAB9A | |
| SCHEMBL28011859 | 0.75 | BACE1 (0.46) | KDM4EALDH1A1METAP2PLK1RAB9A | |
| SCHEMBL17774804 | 0.74 | KDM4E (0.66) | KDM4EALDH1A1GAAGLAPKM | |
| SCHEMBL20631799 | 0.74 | ALDH1A1 (0.66) | KDM4EALDH1A1GAAGLARAB9A | |
| SCHEMBL29893781 | 0.73 | DGAT1 (0.51) | GAAPLK1RAB9ACNR1CNR2 | |
| SCHEMBL28277680 | 0.73 | CNR1 (0.42) | ALDH1A1METAP2PLK1RAB9ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |