Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631602 | 0.82 | MEN1 (0.33) | MEN1POLBKMT2ATRPM8TLR8 | |
| SCHEMBL1916331 | 0.79 | MEN1 (0.35) | MEN1POLBKMT2ATRPM8TLR8 | |
| SCHEMBL9045721 | 0.78 | P2RX3 (0.37) | MEN1POLBKMT2AP2RX3P2RX2 | |
| SCHEMBL5494945 | 0.72 | HTT (0.37) | MEN1POLBKMT2AMAPTLMNA | |
| SCHEMBL16369426 | 0.71 | HSP90AA1 (0.38) | P2RX3P2RX2LMNA | |
| SCHEMBL20665383 | 0.70 | TRPM8 (0.65) | MEN1POLBKMT2ATRPM8MAPT | |
| SCHEMBL6828222 | 0.69 | TRPM8 (0.41) | TRPM8TLR8MCHR1XDHMAPT | |
| SCHEMBL23937861 | 0.69 | L3MBTL1 (0.38) | MEN1KMT2AMAPT | |
| SCHEMBL3396456 | 0.68 | — | — | |
| SCHEMBL29808066 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |