Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.34 |
| ▸ | GGT1 | P19440 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16742632 | 0.83 | HTT (0.38) | HTTTSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4046039 | 0.80 | LMNA (0.42) | HTTTSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5501359 | 0.80 | KDM4E (0.41) | HTTTSHRSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL907644 | 0.79 | TNFSF11 (0.40) | HTTTSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10361048 | 0.77 | ALDH1A1 (0.32) | HTTTSHRALDH1A1KDM4ETDP1 | |
| SCHEMBL9045721 | 0.76 | P2RX3 (0.37) | TSHRSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL5500327 | 0.75 | PDE10A (0.36) | ALDH1A1KDM4ETDP1BLMPTGS2 | |
| SCHEMBL23937860 | 0.72 | PIK3C3 (0.35) | LMNAMAPTKMT2APOLBMEN1 | |
| SCHEMBL17706548 | 0.71 | POLB (0.51) | SMN1; SMN2LMNAALDH1A1KDM4ETDP1 | |
| SCHEMBL24786404 | 0.70 | LMNA (0.50) | TSHRSMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| EP-0222210-B1 | PROCESS FOR PREPARING PHOSPHORIC-ACID DERIVATIVES AND INTERMEDIATES | BAYER AG (DE) | 1990-03-28 | — | — | EP | disclosed |
| US-4769458-A | Process for the preparation of phosphoric acid derivatives and intermediate products | BAYER AKTIENGESELLSCHAFT (DE) | 1988-09-06 | — | — | US | disclosed |
| EP-0222210-A2 | Process for preparing phosphoric-acid derivatives and intermediates | BAYER AG (DE) | 1987-05-20 | — | — | EP | disclosed |