⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20483 | 0.64 | EGFR (0.47) | — | |
| SCHEMBL4054789 | 0.64 | EGFR (0.37) | — | |
| SCHEMBL3935658 | 0.62 | EGFR (0.35) | — | |
| SCHEMBL8311252 | 0.60 | EGFR (0.38) | — | |
| SCHEMBL3934464 | 0.60 | EGFR (0.38) | — | |
| SCHEMBL29809882 | 0.59 | EGFR (0.46) | — | |
| SCHEMBL140301 | 0.59 | EGFR (0.46) | — | |
| SCHEMBL2035779 | 0.59 | — | — | |
| SCHEMBL17511920 | 0.59 | EGFR (0.46) | — | |
| SCHEMBL10932285 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719701-A1 | methods for the preparation of thieno[3,4-d]pyrimidin-7-yl ribosides | GILEAD SCIENCES, INC. (US) | 2014-04-16 | — | — | EP | disclosed |
| CN-102348713-A | CARBA-nucleoside analogs for antiviral treatment | GILEAD SCIENCES INC | 2012-02-08 | — | — | CN | disclosed |
| EP-2396340-A1 | CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| US-8012942-B2 | Carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| WO-2010093608-A1 | CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100203015-A1 | CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2010-08-12 | — | — | US | disclosed |