Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23940249 | 0.84 | BRD4 (0.55) | ALDH1A1KDM4ECREBBPMAPK1BCHE | |
| SCHEMBL23940144 | 0.84 | CREBBP (0.49) | ALDH1A1KDM4ECREBBPBCHEHDAC1 | |
| SCHEMBL23940245 | 0.83 | ALDH1A1 (0.83) | ALDH1A1KDM4ECREBBPHPGDABL1 | |
| SCHEMBL23940202 | 0.82 | LMNA (0.46) | ALDH1A1KDM4ECREBBPMAPK1SMN1; SMN2 | |
| SCHEMBL23940222 | 0.81 | KMT2A (0.47) | ALDH1A1CREBBPPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL13209353 | 0.79 | NR4A2 (0.65) | ALDH1A1KDM4EPOLBSMN1; SMN2TSHR | |
| SCHEMBL23940153 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23940236 | 0.76 | CREBBP (0.51) | ALDH1A1KDM4ECREBBPHPGDSMN1; SMN2 | |
| SCHEMBL15458754 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1KDM4ECREBBPPOLBCYP1A2 | |
| SCHEMBL3924368 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4EPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-21 | — | — | US | disclosed |
| US-20170037399-A1 | CHIRAL DESIGN | WAVE LIFE SCIENCES LTD. (SG) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | TYK2, JAK3, JAK1 | ALDH1A1 2637/4885KDM4E 2484/4885CREBBP 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.