Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 3/20 | 0.35 |
| ▸ | LDHB | P07195 | 3/20 | 0.35 |
| ▸ | BCL2 | P10415 | 3/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | ALB | P02768 | 6/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.32 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19183569 | 0.89 | BCL2 (0.32) | LDHALDHBBCL2MCL1BCL2L1 | |
| SCHEMBL14201680 | 0.89 | LDHA (0.35) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL19972877 | 0.80 | BCL2 (0.33) | LDHALDHBBCL2MCL1BCL2L1 | |
| SCHEMBL19998507 | 0.78 | LDHA (0.37) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL5589113 | 0.78 | LDHA (0.37) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL11813554 | 0.78 | BCL2 (0.32) | LDHALDHBBCL2MCL1BCL2L1 | |
| SCHEMBL5526052 | 0.77 | BCL2 (0.34) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL9070220 | 0.77 | BCL2 (0.34) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL1242989 | 0.76 | BCL2 (0.35) | LDHALDHBBCL2MCL1ALB | |
| SCHEMBL1760594 | 0.75 | GABRA1 (0.38) | LDHALDHBBCL2MCL1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11505531-B2 | Piperazine-2,5-diones as TGF-beta inhibitors | UAB RESEARCH FOUNDATION (US) | 2022-11-22 | — | — | US | disclosed |
| US-20210323933-A1 | PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS | UAB RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323933-A1 | PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS | TGFBR2, SMAD2, TGFB2 | LDHA 4283/4885LDHB 3873/4885BCL2 199/4885 |
| US-11505531-B2 | Piperazine-2,5-diones as TGF-beta inhibitors | TGFBR2, SMAD2, TGFB2 | LDHA 4283/4885LDHB 3873/4885BCL2 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.