Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | STAT5A | P42229 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18239659 | 0.80 | HTR2A (0.44) | JAK3STAT5AZAP70SYKKDM4E | |
| SCHEMBL23944981 | 0.74 | CHRM2 (0.30) | CHRM2CHRNA7 | |
| SCHEMBL23944977 | 0.70 | PER2 (0.36) | KDM4EMAPTPTGDR2PTGDRTBXA2R | |
| SCHEMBL19960987 | 0.69 | HTR2A (0.42) | KDM4EMAPTHTR2AHTR2C | |
| SCHEMBL19960980 | 0.66 | HTR2A (0.36) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL18239591 | 0.65 | JAK3 (0.37) | JAK3STAT5AZAP70SYKPTGDR2 | |
| SCHEMBL9382916 | 0.65 | SIGMAR1 (0.47) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19960979 | 0.65 | HTR2A (0.38) | KDM4EMAPTHTR2AHTR2C | |
| SCHEMBL19960977 | 0.64 | HTR2A (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19960988 | 0.63 | PER2 (0.40) | JAK3KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ERBB2, EGFR, ERBB3 | JAK3 331/4885STAT5A 580/4885ZAP70 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.