Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639757 | 0.93 | TSHR (0.50) | TSHREPHX2HDAC1HDAC2HDAC6 | |
| SCHEMBL2394516 | 0.92 | ALDH1A1 (0.48) | TSHRALDH1A1EPHX2CA1DGKA | |
| Hydrochloric Acid SCHEMBL7239543 | 0.90 | TSHR (0.48) | TSHREPHX2HDAC1HDAC2HDAC6 | |
| SCHEMBL134923 | 0.87 | EPHX2 (0.46) | TSHRALDH1A1EPHX2HDAC1HDAC2 | |
| SCHEMBL28344542 | 0.86 | TSHR (0.46) | TSHRALDH1A1EPHX2TDP1MEN1 | |
| SCHEMBL28601206 | 0.86 | TSHR (0.46) | TSHRALDH1A1EPHX2TDP1MEN1 | |
| SCHEMBL3914424 | 0.85 | EPHX2 (0.49) | TSHRALDH1A1EPHX2HDAC1HDAC2 | |
| SCHEMBL20450540 | 0.85 | EPHX2 (0.49) | TSHRALDH1A1EPHX2HDAC1HDAC2 | |
| SCHEMBL14482131 | 0.85 | EPHX2 (0.49) | TSHRALDH1A1EPHX2HDAC1HDAC2 | |
| SCHEMBL2380206 | 0.85 | EPHX2 (0.49) | TSHRALDH1A1EPHX2HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9245290-B2 | Caspase inhibitors and uses thereof | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140011847-A1 | CASPASE INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-01-09 | — | — | US | disclosed |
| US-8518942-B2 | Caspase inhibitors and uses thereof | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110230527-A1 | CASPASE INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-09-22 | — | — | US | disclosed |
| WO-2010017408-A1 | CASPASE INHIBITORS AND USES THEREOF | THE BUCK INSTITUTE FOR AGE RESEARCH (US) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230527-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP6, CASP3, CASP2 | TSHR 4710/4885ALDH1A1 4178/4885EPHX2 2543/4885 |
| US-20140011847-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP6, CASP3, CASP2 | TSHR 4710/4885ALDH1A1 4178/4885EPHX2 2543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.