Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367472 | 0.84 | NR4A2 (0.59) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2009003 | 0.83 | ALOX15 (0.62) | MAPTNOTUMNAMPTLMNA | |
| SCHEMBL1068092 | 0.82 | MAPT (0.69) | MAPTRAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL31407246 | 0.81 | L3MBTL1 (0.63) | PLOD2MAPTRAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6067927 | 0.81 | ALOX15 (0.60) | MAPTNOTUMNAMPTKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL29642862 | 0.81 | ALOX15 (0.60) | MAPTNOTUMNAMPTKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8136104 | 0.81 | MAPT (0.67) | MAPTRAB9ANPC1SMN1; SMN2TDP1 | |
| Methane SCHEMBL28765047 | 0.81 | MAPT (0.67) | MAPTRAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL2394579 | 0.79 | MAPT (0.51) | PLOD2MAPTNOTUMNAMPTRAB9A | |
| SCHEMBL2394586 | 0.79 | MAPT (0.51) | PLOD2MAPTNOTUMNAMPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |