Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394579 | 1.00 | MAPT (0.51) | MAPTNOTUMCHRNB2CHRNA4NAMPT | |
| SCHEMBL31351884 | 0.85 | ALOX15 (0.50) | MAPTGAADRD4 | |
| SCHEMBL2394339 | 0.82 | MAPT (0.47) | MAPTNOTUMCHRNB2CHRNA4NAMPT | |
| SCHEMBL2394334 | 0.82 | MAPT (0.47) | MAPTNOTUMCHRNB2CHRNA4NAMPT | |
| SCHEMBL2394585 | 0.79 | PLOD2 (0.58) | MAPTNOTUMNAMPTGALR3RAB9A | |
| SCHEMBL2009003 | 0.75 | ALOX15 (0.62) | MAPTNOTUMCHRNB2CHRNA4NAMPT | |
| SCHEMBL9323799 | 0.74 | NAPRT (0.54) | RAB9ATDP1HTTPLOD2GAA | |
| SCHEMBL9323795 | 0.74 | NAPRT (0.54) | RAB9ATDP1HTTPLOD2GAA | |
| SCHEMBL20491186 | 0.74 | GAA (0.50) | MAPTGAADRD4 | |
| SCHEMBL2396340 | 0.74 | SLC6A4 (0.51) | MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |