Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950198 | 0.84 | ALOX15 (0.47) | PIK3CATP53POLBMAPTNLRP3 | |
| SCHEMBL23950524 | 0.79 | KDM4E (0.47) | POLB | |
| SCHEMBL23950616 | 0.75 | NLRP3 (0.50) | TP53POLBMAPTNLRP3 | |
| SCHEMBL23950196 | 0.75 | TP53 (0.56) | TP53MAPTNLRP3NPC1 | |
| SCHEMBL23950623 | 0.73 | TP53 (0.52) | TP53POLBNLRP3NPC1 | |
| SCHEMBL23950622 | 0.70 | POLB (0.60) | TP53POLBMAPT | |
| SCHEMBL23925544 | 0.70 | PDE4B (0.34) | PIK3CABRD9 | |
| SCHEMBL4194913 | 0.69 | PIK3CA (0.36) | PIK3CAPOLB | |
| SCHEMBL15185707 | 0.67 | KMT2A (0.38) | TBXAS1MAPTNPC1 | |
| SCHEMBL14084736 | 0.63 | RAB9A (0.42) | POLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |