Sugi Predict

Sugi Predict / Compounds / SCHEMBL23925544

SCHEMBL23925544

SCHEMBL23925544

CCc1n[nH]c(=O)c2ccnn12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 3/20 0.34
▸ PDE3A Q14432 3/20 0.34
▸ PDE2A O00408 2/20 0.34
▸ PDE6D O43924 2/20 0.34
▸ PDE8A O60658 2/20 0.34
▸ PDE5A O76074 2/20 0.34
▸ PDE9A O76083 2/20 0.34
▸ PDE8B O95263 2/20 0.34
▸ PDE6A P16499 2/20 0.34
▸ PDE6G P18545 2/20 0.34
▸ PDE4A P27815 2/20 0.34
▸ PDE6B P35913 2/20 0.34
▸ PDE6C P51160 2/20 0.34
▸ PDE1A P54750 2/20 0.34
▸ PDE1B Q01064 2/20 0.34
▸ PDE4C Q08493 2/20 0.34
▸ PDE4D Q08499 2/20 0.34
▸ PDE3B Q13370 2/20 0.34
▸ PDE7A Q13946 2/20 0.34
▸ PDE6H Q13956 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23950312 0.74 KDM4E (0.31) GAA
SCHEMBL21419936 0.70 MAPT (0.41) PDE4BPDE3APDE2APDE6DPDE8A
SCHEMBL23950203 0.70 PIK3CA (0.39) BRD9PIK3CA
SCHEMBL25633263 0.67 NPC1 (0.46) PDE4BPDE3APDE2APDE6DPDE8A
SCHEMBL11641336 0.67 GABRA5 (0.39) PDE4BPDE3APDE2APDE6DPDE8A
SCHEMBL23950198 0.66 ALOX15 (0.47) PIK3CA
SCHEMBL25633269 0.65 TP53 (0.52) PDE4BPDE3APDE2APDE6DPDE8A
SCHEMBL25633268 0.65 TP53 (0.41) PDE4BPDE3APDE2APDE6DPDE8A
SCHEMBL23952161 0.65 KDM4E (0.31) GAA
SCHEMBL25360546 0.64 LMNA (0.36) PDE4BPDE3APDE2APDE6DPDE8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230203044-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME JANSSEN PHARMACEUTICA NV (BE) 2023-06-29 — — US disclosed
US-20230203044-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME JANSSEN PHARMACEUTICA NV (BE) 2023-06-29 — — US disclosed
US-20230203044-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME JANSSEN PHARMACEUTICA NV (BE) 2023-06-29 — — US disclosed
EP-4135843-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY JANSSEN Pharmaceutica NV (BE) 2023-02-22 — — EP disclosed
CN-115427110-A Pyrazolo [1,5-D ] [1,2,4] triazine-5 (4H) acetamide as an NLRP3 inflammatory pathway inhibitor 詹森药业有限公司 2022-12-02 — — CN disclosed
WO-2021209552-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY JANSSEN PHARMACEUTICA NV (BE) 2021-10-21 — — WO disclosed
WO-2021209552-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY JANSSEN PHARMACEUTICA NV (BE) 2021-10-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230203044-A1 PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME NLRP3, PYCARD, NLRP1 PDE4B 548/4885PDE3A 1216/4885PDE2A 1236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.