Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.42 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | KDM1A | O60341 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.36 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28555751 | 0.79 | MAOA (0.44) | MAOAMAOBKDM1AALDH1A1LMNA | |
| SCHEMBL23950409 | 0.76 | MAOA (0.61) | MAOAMAOBKDM1AALDH1A1LMNA | |
| SCHEMBL29214271 | 0.73 | HSD11B1 (0.41) | MAOAMAOBKDM1AALDH1A1HSD11B1 | |
| SCHEMBL28166051 | 0.72 | MAOA (0.50) | MAOAMAOBKDM1ALMNA | |
| SCHEMBL7434413 | 0.72 | MAOA (0.39) | MAOAMAOBKDM1AALDH1A1LMNA | |
| SCHEMBL7444026 | 0.72 | MAOA (0.39) | MAOAMAOBKDM1AALDH1A1LMNA | |
| SCHEMBL20440668 | 0.69 | OPRK1 (0.45) | ALDH1A1FUCA1 | |
| SCHEMBL7450746 | 0.68 | ALDH1A1 (0.39) | MAOAMAOBKDM1AALDH1A1LMNA | |
| SCHEMBL19135880 | 0.68 | FUCA1 (0.43) | ALDH1A1HSD11B1FUCA1 | |
| SCHEMBL39509 | 0.68 | KMT2A (0.44) | ALDH1A1FUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |